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, 77 (7), 4336-9

Correlation Between Spontaneous Metastatic Potential, Platelet-Aggregating Activity of Cell Surface Extracts, and Cell Surface Sialylation in 10 Metastatic-Variant Derivatives of a Rat Renal Sarcoma Cell Line

Correlation Between Spontaneous Metastatic Potential, Platelet-Aggregating Activity of Cell Surface Extracts, and Cell Surface Sialylation in 10 Metastatic-Variant Derivatives of a Rat Renal Sarcoma Cell Line

E Pearlstein et al. Proc Natl Acad Sci U S A.

Abstract

Several properties of 10 cell lines derived from the polyoma-induced PW20 Wistar-Furth rat renal sarcoma have been examined, including the ability of the tumor cells to metastasize spontaneously from subcutaneous sites in syngeneic hosts, the platelet-aggregating activity of material extracted by urea from the surface of cultured cells, the sialic acid content of the platelet-aggregating material, and the degree of sialylation of cell surface glycoconjugates in cultured cells. A correlation has been observed among all of these parameters. The results suggest a possible link between the degree of cell surface sialylation of tumor cells, their ability to aggregate platelets, and their ability to metastasize.

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