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, 78 (9), 5722-3

Hyperoxia and Hypoxia in Pregnancy: Simple Experimental Manipulation Alters the Incidence of Cleft Lip and Palate in CL/Fr Mice

Hyperoxia and Hypoxia in Pregnancy: Simple Experimental Manipulation Alters the Incidence of Cleft Lip and Palate in CL/Fr Mice

G Millicovsky et al. Proc Natl Acad Sci U S A.

Abstract

This paper describes alterations in the incidence of cleft lip and palate in CL/Fr mice subsequent to experimental manipulation of maternal respiratory oxygen levels during a critical period of pregnancy. Only a few previous studies have shown that the incidence of some "genetically determined" malformations in mammals can be decreased by environmental procedures. In addition to demonstrating a decreased incidence of cleft lip and palate subsequent to maternal hyperoxia on gestational days 10 and 11 in a genetically susceptible strain, the results of the present study show that hypoxia at this time increases the incidence of cleft lip and palate.

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References

    1. C R Acad Sci Hebd Seances Acad Sci D. 1971 Dec 20;273(25):2639-42 - PubMed
    1. Science. 1966 Jun 24;152(3730):1766-8 - PubMed
    1. Teratology. 1977 Apr;15(2):149-57 - PubMed
    1. Teratology. 1980 Aug;22(1):115-24 - PubMed
    1. Science. 1981 May 8;212(4495):671-2 - PubMed

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