Abstract
We found HLA-DR5 to be present among 53% of 40 patients with goitrous autoimmune (Hashimoto's ) thyroiditis compared to 26% of 80 controls. No deviations from those expected in the incidences of HLA-A, B, C antigens were seen. In contrast HLA-DR3 was increased among 50 patients with atrophic thyroiditis (65%) compared to controls (24%). These findings stress the immunogenetic heterogeneity between the goitrous and atrophic varieties of thyroiditis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibody Formation
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Autoimmune Diseases / complications*
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Autoimmune Diseases / immunology
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Genetic Linkage
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Goiter / complications*
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Goiter / immunology
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Histocompatibility Antigens Class II / genetics*
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Humans
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Microsomes / immunology
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Thyroglobulin / immunology
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Thyroiditis / immunology
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Thyroiditis, Autoimmune / complications*
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Thyroiditis, Autoimmune / immunology
Substances
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Histocompatibility Antigens Class II
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Thyroglobulin