The association of goitrous autoimmune thyroiditis with HLA-DR5

Tissue Antigens. 1981 Mar;17(3):265-8. doi: 10.1111/j.1399-0039.1981.tb00700.x.

Abstract

We found HLA-DR5 to be present among 53% of 40 patients with goitrous autoimmune (Hashimoto's ) thyroiditis compared to 26% of 80 controls. No deviations from those expected in the incidences of HLA-A, B, C antigens were seen. In contrast HLA-DR3 was increased among 50 patients with atrophic thyroiditis (65%) compared to controls (24%). These findings stress the immunogenetic heterogeneity between the goitrous and atrophic varieties of thyroiditis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibody Formation
  • Autoimmune Diseases / complications*
  • Autoimmune Diseases / immunology
  • Genetic Linkage
  • Goiter / complications*
  • Goiter / immunology
  • Histocompatibility Antigens Class II / genetics*
  • Humans
  • Microsomes / immunology
  • Thyroglobulin / immunology
  • Thyroiditis / immunology
  • Thyroiditis, Autoimmune / complications*
  • Thyroiditis, Autoimmune / immunology

Substances

  • Histocompatibility Antigens Class II
  • Thyroglobulin