Growth and characterization of childhood rhabdomyosarcomas as xenografts

J Natl Cancer Inst. 1982 Mar;68(3):437-43.

Abstract

Eleven surgical specimens of childhood rhabdomyosarcoma (RMS), two bone marrow samples, and cells from ascitic fluid from 1 patient were implanted sc into immune-deprived inbred CBA/CaJ mice. From these, seven lines of RMS were obtained as xenografts, each retaining the histologic characteristics of the tumor of origin and human lactate dehydrogenase isozymes; these represented 6 of the 11 surgical specimens, whereas one line originated from the transplanted cells from ascitic fluid. It was concluded that children RMS has a fairly high frequency of heterotransplantability in this system and that such a laboratory model may prove useful in the development of new therapeutic regimens in this disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Animals
  • Child
  • Disease Models, Animal*
  • Female
  • Humans
  • Immunosuppression
  • Mice
  • Mice, Inbred CBA
  • Neoplasm Transplantation
  • Neoplasms, Experimental / immunology
  • Neoplasms, Experimental / pathology
  • Rhabdomyosarcoma / immunology
  • Rhabdomyosarcoma / pathology*
  • Transplantation, Heterologous