Studies of retinoids in the prevention and treatment of cancer

J Am Acad Dermatol. 1982 Apr;6(4 Pt 2 Suppl):824-7. doi: 10.1016/s0190-9622(82)70072-6.

Abstract

Investigation of retinoids for anticancer activity in humans, either in the chemopreventive or treatment mode, has been little studied. We summarize here our ongoing investigations in four different areas: (1) secondary prevention of cervical dysplasia with topical application of all-trans-retinoic acid; (2) adjuvant treatment of resected high-risk stage I and II malignant melanoma with bacille Calmette Guérin (BCG) plus or minus oral vitamin A; (3) topical vitamin A acid therapy for cutaneous metastatic melanoma; an (4) oral isotretinoin as an anticancer agent.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Diterpenes
  • Female
  • Humans
  • Isomerism
  • Isotretinoin
  • Melanoma / drug therapy
  • Neoplasms / drug therapy*
  • Neoplasms / prevention & control*
  • Palmitates / therapeutic use
  • Skin Neoplasms / drug therapy
  • Tretinoin / therapeutic use
  • Uterine Cervical Dysplasia / prevention & control
  • Vitamin A / analogs & derivatives*
  • Vitamin A / therapeutic use

Substances

  • Diterpenes
  • Palmitates
  • Vitamin A
  • retinol palmitate
  • Tretinoin
  • Isotretinoin