Allelic exclusion of immunoglobulin expression is not caused by somatic segregation

Proc Natl Acad Sci U S A. 1982 Jan;79(2):606-7. doi: 10.1073/pnas.79.2.606.


We have investigated the karyotype of immunoglobulin-producing cells in heterozygous animals. Using a karyotypic marker for one homolog of a chromosome carrying immunoglobulin genes, we established that immunoglobulin-producing cells are heterozygous with respect to this chromosome. Therefore, allelic exclusion of immunoglobulin expression cannot be caused by somatic chromosome segregation.

MeSH terms

  • Alleles
  • Animals
  • Heterozygote
  • Immunoglobulin Allotypes / genetics*
  • Immunoglobulin D / genetics*
  • Immunoglobulin M / genetics*
  • Karyotyping
  • Mice
  • Receptors, Antigen, B-Cell / genetics


  • Immunoglobulin Allotypes
  • Immunoglobulin D
  • Immunoglobulin M
  • Receptors, Antigen, B-Cell