The giant cell fibroma. A review of 464 cases

Oral Surg Oral Med Oral Pathol. 1982 Jun;53(6):582-7. doi: 10.1016/0030-4220(82)90344-9.


The biopsy service at Indiana University School of Dentistry, Department of Oral Pathology, accessioned 464 cases of giant cell fibroma from February, 1971, until May, 1980. From a study of these cases, it appears that the giant cell fibroma is a distinctive lesion with a characteristic age distribution, location, sex incidence, and histologic appearance. Clinically, the giant cell fibroma presents as an asymptomatic, papillary, pedunculated lesion, commonly regarded as a papilloma. It is fairly common in young persons and usually occurs on the gingiva. No sex predilection has been noted, and simple surgical excision appears to be the treatment of choice.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Diagnosis, Differential
  • Female
  • Fibroma / pathology*
  • Gingival Neoplasms / pathology
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms / pathology*
  • Papilloma / pathology