Thymosin beta 4: a ubiquitous peptide in rat and mouse tissues

Proc Natl Acad Sci U S A. 1982 Apr;79(7):2172-5. doi: 10.1073/pnas.79.7.2172.


Thymosin beta 4, recently isolated from calf thymus, is present in a number of rat and mouse tissues, including spleen, thymus, brain, lung, liver, and heart muscle. High concentrations are found in peritoneal macrophages, suggesting that its occurrence in other tissues may be related to the presence of macrophages or macrophage-like cells in these tissues. The conclusion that "thymosin" beta 4 does not originate solely in the thymus gland is supported by the high concentrations found in tissues of athymic (nu/nu) mice.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Ascitic Fluid / cytology
  • Brain / metabolism
  • Chromatography, High Pressure Liquid
  • Macrophages / metabolism
  • Mice
  • Mice, Nude / metabolism
  • Rats
  • Species Specificity
  • Spleen / metabolism
  • Thymosin / analogs & derivatives*
  • Thymosin / metabolism*
  • Thymus Gland / metabolism
  • Thymus Hormones* / metabolism*
  • Tissue Distribution


  • Thymus Hormones
  • Thymosin