Common 82-nucleotide sequence unique to brain RNA

Proc Natl Acad Sci U S A. 1982 Aug;79(16):4942-6. doi: 10.1073/pnas.79.16.4942.


Several randomly selected cDNA clones made from rat brain polyA+RNA have unusual properties. Although the cDNA inserts are 500-1,250 base pairs long, they hybridize to a 160-nucleotide RNA species that is present in brain but not in liver or kidney. Nucleotide sequence studies of two of the clones and hybridization studies show that a common 82-nucleotide sequence is responsible for the hybridization. The same sequence is located in the second intron of a rat growth hormone gene. These studies suggest that signals called "ID sequences" may be carried in the introns of genes and prescribe their tissue-specific expression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Brain / physiology*
  • Cell Differentiation*
  • DNA / genetics
  • Gene Expression Regulation
  • Nucleic Acid Hybridization
  • RNA, Messenger / genetics*


  • RNA, Messenger
  • DNA

Associated data

  • GENBANK/J01878
  • GENBANK/J01879