Concentration-dependent sodium chloride transport as the signal in feedback control of glomerular filtration rate

Kidney Int Suppl. 1982 Aug;12:S82-9.


There is good evidence that the initial step leading to a feedback response is the concentration-dependent active transport of sodium chloride across the macula densa cells. This may lead to changes in sodium chloride concentration or tonicity in the small and relatively unstirred compartment of the juxtaglomerular interstitium or to changes in the concentration of transport-related compounds or metabolites. We assume that the Goormaghtigh cells act as receptor cells that transform such compositional changes into a signal propagating to the glomerular vascular elements.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport
  • Dose-Response Relationship, Drug
  • Feedback
  • Furosemide / pharmacology
  • Glomerular Filtration Rate*
  • Humans
  • Kidney Tubules, Distal / physiology
  • Loop of Henle / metabolism
  • Osmolar Concentration
  • Sodium Chloride / metabolism*
  • Sodium Chloride / pharmacology


  • Sodium Chloride
  • Furosemide