Two human c-onc genes are located on the long arm of chromosome 8

Proc Natl Acad Sci U S A. 1982 Dec;79(24):7842-6. doi: 10.1073/pnas.79.24.7842.

Abstract

We have used in situ chromosome hybridization techniques to map the human cellular counterparts (c-onc genes) of the transforming genes of two RNA tumor viruses on human meiotic pachytene and somatic metaphase chromosomes. We find that the human c-mos gene is located on chromosome 8 at a position corresponding to band 8q22 on the somatic map. The human c-myc gene is found on chromosome 8 at position 8q24. These regions on the long arm of chromosome 8 have been previously reported to be involved in specific translocations found in the M-2 subset of acute nonlymphoblastic leukemias. Burkitt lymphoma, and other forms of non-Hodgkin lymphoma, and a familial abnormality that predisposes to renal cell carcinoma. These results suggest that translocations of the human c-mos or c-myc genes may be causally related to neoplastic transformation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Banding
  • Chromosome Mapping
  • Chromosomes, Human, 6-12 and X*
  • Genes, Viral
  • Humans
  • Nucleic Acid Hybridization
  • Oncogenes*
  • Retroviridae / genetics