Sunscreens prevent ultraviolet photocarcinogenesis

J Am Acad Dermatol. 1980 Jul;3(1):30-5. doi: 10.1016/s0190-9622(80)80221-0.

Abstract

Sunscreens of low or high sun protection factors (SPF*) were tested for their ability to inhibit ultraviolet (UV) carcinogenesis in two varieties of hairless mice. Low protection (SPF = 2) reduced by 50% the number of albino animals developing tumors. High protection (SPF =15) prevented tumor formation. Tumorigenesis was totally prevented in the lightly pigmented variety with either sunscreen, demonstrating the added protection of melanin. In mice and man, UV-induced cancer is a cumulative process. Reducing the amount of UV light reaching the basal layer will retard that process.

MeSH terms

  • 4-Aminobenzoic Acid / administration & dosage
  • 4-Aminobenzoic Acid / therapeutic use*
  • Aminobenzoates / therapeutic use*
  • Animals
  • Benzophenones / administration & dosage
  • Benzophenones / therapeutic use
  • Drug Combinations
  • Mice
  • Mice, Nude
  • Neoplasms, Experimental / prevention & control
  • Neoplasms, Radiation-Induced / prevention & control*
  • Skin Neoplasms / prevention & control*
  • Skin Pigmentation / radiation effects
  • Sunscreening Agents / administration & dosage
  • Sunscreening Agents / therapeutic use*
  • Ultraviolet Rays*

Substances

  • Aminobenzoates
  • Benzophenones
  • Drug Combinations
  • Sunscreening Agents
  • oxybenzone
  • 4-Aminobenzoic Acid