Antimicrobial drug susceptibility of respiratory isolates of Hemophilus influenzae from adults

Am Rev Respir Dis. 1980 Jul;122(1):61-4. doi: 10.1164/arrd.1980.122.1.61.


Hemophilus influenzae isolates from sputum of 111 patients with chronic bronchitis were tested for susceptibility to 8 antimicrobial drugs. A new beta-lactam, LY-127935, was the most active agent tested. Ampicillin, cefamandole, tetracycline, and cefuroxime showed good activity against most isolates. Two strains, both nontypable, were resistant to ampicillin and produced beta-lactamase. Cefaclor was somewhat less effective, although most strains were susceptible. Erythromycin and cephalexin were of limited utility.

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Bronchitis / microbiology*
  • Haemophilus influenzae / drug effects*
  • Haemophilus influenzae / enzymology
  • Humans
  • Microbial Sensitivity Tests
  • Sputum / microbiology
  • beta-Lactamases / metabolism


  • Anti-Bacterial Agents
  • beta-Lactamases