Effects of protein deficiency on plasma levels of 25-hydroxyvitamin and 24,25-dihydroxyvitamin D in the rat

Am J Clin Nutr. 1980 Oct;33(10):2174-6. doi: 10.1093/ajcn/33.10.2174.


The effect of protein deficiency on plasma 25-hydroxyvitamin and 24,25-dihydroxyvitamin D concentrations was determined in weanling rats. The concentrations of these metabolites did not differ in rats fed diet providing either 0.5 or 21% casein for 4 weeks postweaning. Also, no change was observed in plasma levels of these metabolites in rats fed the 21% casein diet in amounts restricted to those consumed by the 0.5% casein animals for the same period of time. The results indicate that the synthesis and transport of 25-hydroxyvitamin and 24,25-dihydroxyvitamin D are not significantly affected by either a protein deficiency or a total food striction during the early postweaning period. This finding may be relevant to the vitamin D status of children with kwashiorkor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 24,25-Dihydroxyvitamin D 3
  • 25-Hydroxyvitamin D 2
  • Animals
  • Caseins / administration & dosage
  • Diet
  • Dihydroxycholecalciferols / blood*
  • Hydroxycholecalciferols / blood*
  • Male
  • Protein Deficiency / metabolism*
  • Rats


  • Caseins
  • Dihydroxycholecalciferols
  • Hydroxycholecalciferols
  • 25-Hydroxyvitamin D 2
  • 24,25-Dihydroxyvitamin D 3