Study on the effects of L-5HTP on the stages of sleep in man as evaluated by using sleep deprivation

Folia Psychiatr Neurol Jpn. 1980;34(2):83-7. doi: 10.1111/j.1440-1819.1980.tb01516.x.

Abstract

The effects of L-5HTP 200 mg on the EEG sleep pattern were investigated in normal subjects. When L-5HTP 200 mg was orally administered, only % S1 significantly decreased in comparison with the baseline. There was no change in any sleep stage on the first recovery night. On the second recovery night, % S1 significantly decreased, while % SR increased significantly. SWS did not show any change. The effects of L-5HTP 200 mg were investigated on the first recovery night after one night of sleep deprivation. SWS significantly increased on the first recovery night when a placebo was given, while this rebound increase of SWS disappeared and % S2 significantly increased on the first recovery night when L-5HTP was given. % SR significantly increased on the next night after the L-5HTP night.

MeSH terms

  • 5-Hydroxytryptophan / pharmacology*
  • Adult
  • Humans
  • Norepinephrine / metabolism
  • Sleep Deprivation
  • Sleep Stages / drug effects*
  • Sleep, REM / drug effects
  • Time Factors

Substances

  • 5-Hydroxytryptophan
  • Norepinephrine