Biochemical separation of interleukin 2

J Immunol Methods. 1980;39(3):185-201. doi: 10.1016/0022-1759(80)90055-1.


Interleukin 2 (IL-2) is a class of T cell growth factors produced by T cells of a number of species. The unique growth-promoting properties of these molecules allow the development of antigen-specific effector T cell lines which can be used to analyze the molecular basis of lymphocyte interactions. A murine T cell tumor line has been identified as a source of IL-2. The purification and biochemical properties of murine IL-2 are described, and compared with rat and human Il-2.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromatography, Gel
  • Chromatography, Ion Exchange
  • Electrophoresis, Polyacrylamide Gel
  • Female
  • Growth Substances / isolation & purification*
  • Humans
  • Interleukin-2 / isolation & purification*
  • Isoelectric Focusing
  • Lymphokines / isolation & purification*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Nude
  • Rats
  • T-Lymphocytes*


  • Growth Substances
  • Interleukin-2
  • Lymphokines