Abstract
Interleukin 2 (IL-2) is a class of T cell growth factors produced by T cells of a number of species. The unique growth-promoting properties of these molecules allow the development of antigen-specific effector T cell lines which can be used to analyze the molecular basis of lymphocyte interactions. A murine T cell tumor line has been identified as a source of IL-2. The purification and biochemical properties of murine IL-2 are described, and compared with rat and human Il-2.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Chromatography, Gel
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Chromatography, Ion Exchange
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Electrophoresis, Polyacrylamide Gel
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Female
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Growth Substances / isolation & purification*
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Humans
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Interleukin-2 / isolation & purification*
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Isoelectric Focusing
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Lymphokines / isolation & purification*
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Nude
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Rats
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T-Lymphocytes*
Substances
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Growth Substances
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Interleukin-2
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Lymphokines