Abstract
Mitochondrial preparations from 4 human kidneys produced 1,25-dihydroxycholecalciferol and 24,25 dihydroxycholecalciferol at rates of 0.019 - 0.114 and 0.029 - 0.164 pmol/mg/min respectively at a 25-hydroxycholecalciferol concentration of 1 mumol per litre. Mitochondria from a fifth kidney failed to produce either metabolite.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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24,25-Dihydroxyvitamin D 3
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Calcitriol
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Dihydroxycholecalciferols / biosynthesis*
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Humans
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Hydroxycholecalciferols / biosynthesis*
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Kidney / metabolism*
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Kinetics
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Mitochondria / metabolism*
Substances
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Dihydroxycholecalciferols
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Hydroxycholecalciferols
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24,25-Dihydroxyvitamin D 3
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Calcitriol