The synthesis of dihydroxylated vitamin D metabolites by human renal mitochondria

J Clin Endocrinol Metab. 1981 Aug;53(2):450-2. doi: 10.1210/jcem-53-2-450.

Abstract

Mitochondrial preparations from 4 human kidneys produced 1,25-dihydroxycholecalciferol and 24,25 dihydroxycholecalciferol at rates of 0.019 - 0.114 and 0.029 - 0.164 pmol/mg/min respectively at a 25-hydroxycholecalciferol concentration of 1 mumol per litre. Mitochondria from a fifth kidney failed to produce either metabolite.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 24,25-Dihydroxyvitamin D 3
  • Calcitriol
  • Dihydroxycholecalciferols / biosynthesis*
  • Humans
  • Hydroxycholecalciferols / biosynthesis*
  • Kidney / metabolism*
  • Kinetics
  • Mitochondria / metabolism*

Substances

  • Dihydroxycholecalciferols
  • Hydroxycholecalciferols
  • 24,25-Dihydroxyvitamin D 3
  • Calcitriol