IgA glomerular deposits in experimental cirrhosis

Am J Pathol. 1981 Jul;104(1):50-4.


Lewis rats rendered cirrhotic by the administration of carbon tetrachloride developed mesangial and glomerular capillary wall deposits of immunoglobulins (especially IgA) and complement. These rats also had circulating immune complexes and markedly elevated serum IgA concentrations. The model suggests that defective hepatic sequestration of circulating IgA polymers and immune complexes may be responsible for the glomerular deposits. A similar mechanism may account for the high incidence of glomerulonephritis in patients with alcoholic cirrhosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigen-Antibody Complex
  • Ascites / complications
  • Immunoglobulin A*
  • Immunoglobulin M
  • Kidney Glomerulus / immunology*
  • Kidney Glomerulus / ultrastructure
  • Liver Cirrhosis, Experimental / complications
  • Liver Cirrhosis, Experimental / diagnosis
  • Liver Cirrhosis, Experimental / immunology*
  • Male
  • Rats
  • Rats, Inbred Lew
  • Splenomegaly / complications
  • Testicular Diseases / complications


  • Antigen-Antibody Complex
  • Immunoglobulin A
  • Immunoglobulin M