Histiocytosis X--an immune deficiency disease? Studies on antibody-dependent monocyte-mediated cytotoxicity

Br J Dermatol. 1981 Jul;105(1):13-8. doi: 10.1111/j.1365-2133.1981.tb00877.x.

Abstract

Six children with histiocytosis X, all in clinical remission, were investigated for antibody-dependent cytotoxicity mediated by monocytes and neutrophils. Monocytes demonstrated a reduced cytotoxicity and a normal Fc receptor activity. Judged by light microscopy the monocytes were normal. Preincubation with the patient's serum did not influence the cytotoxicity of normal monocytes. Neutrophils from patients with histiocytosis X showed a normal cytotoxic activity. We postulate a functional defect of the mononuclear phagocyte system in histiocytosis X.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibody-Dependent Cell Cytotoxicity*
  • Child
  • Child, Preschool
  • Female
  • Histiocytosis, Langerhans-Cell / immunology*
  • Humans
  • Male
  • Monocytes / immunology*
  • Neutrophils / immunology
  • Rosette Formation