Surface alterations of mammalian cells upon ionizing radiation as detected by lectin-binding technique. II. Binding of concanavalin A by human blood cells X-irradiated in vitro

T Kubasova; G J Köteles; L P Varga

doi:10.1080/09553008114551061

Surface alterations of mammalian cells upon ionizing radiation as detected by lectin-binding technique. II. Binding of concanavalin A by human blood cells X-irradiated in vitro

Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Aug;40(2):187-94. doi: 10.1080/09553008114551061.

Authors

T Kubasova, G J Köteles, L P Varga

PMID: 6974147
DOI: 10.1080/09553008114551061

Abstract

Early, dose-dependent and transient alterations were observed in the plasma membranes of human blood cells after X-irradiation in vitro as detected by a concanavalin A-binding technique. Platelets, lymphocytes and erythrocytes, separated in a one-step procedure from a single blood sample, showed different radiosensitivities within the dose range of 0.1--5 Gy. The complex evaluation of the surface alterations of blood cells might indicate the range of the absorbed dose.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Binding Sites
Blood Cells / radiation effects*
Blood Platelets / radiation effects
Cell Membrane / radiation effects
Cell Survival
Concanavalin A / metabolism*
Dose-Response Relationship, Radiation
Erythrocytes / radiation effects
Humans
In Vitro Techniques
Lymphocytes / radiation effects
Tritium
X-Rays

Substances

Tritium
Concanavalin A