Antibodies to Sm in patients with systemic lupus erythematosus. Correlation of Sm antibody titers with disease activity and other laboratory parameters

Arthritis Rheum. 1981 Oct;24(10):1236-44. doi: 10.1002/art.1780241003.


Thirty patients with systemic lupus erythematosus (SLE) were studied over a 2.5-year period. The group was divided into 14 patients with antibodies to Sm and a control group that failed to exhibit antibodies to Sm over the study period. The titer of antibodies to Sm fluctuated in all 14. A rising titer of antibodies to Sm 1) predicted a flare disease in 50% an 2) correlated with an exacerbation of disease in 60%. Patients with antibodies to Sm had a comparable incidence of severe disease, renal disease, and central nervous system disease. They exhibited significantly more leukopenia and antibodies to non-Sm, non-RNP extractable nuclear antigen. In only 1 patient, a rise in titer of antibodies to Sm did not correlate with or predict a disease flare in contradistinction to other serologic markers of SLE, specifically antibodies to double-stranded DNA and cryoglobulins. Though infrequently detected, antibodies to Sm can help in the management of patients with SLE.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Antinuclear / analysis*
  • Antigen-Antibody Complex / analysis
  • Antigens / immunology*
  • Autoantigens
  • Central Nervous System Diseases / immunology
  • DNA / immunology
  • Female
  • Humans
  • Kidney Diseases / immunology
  • Leukopenia / immunology
  • Lupus Erythematosus, Systemic / immunology*
  • Lupus Erythematosus, Systemic / physiopathology
  • Male
  • Middle Aged
  • Ribonucleoproteins / immunology
  • Ribonucleoproteins, Small Nuclear*
  • Vasculitis / immunology
  • snRNP Core Proteins


  • Antibodies, Antinuclear
  • Antigen-Antibody Complex
  • Antigens
  • Autoantigens
  • Ribonucleoproteins
  • Ribonucleoproteins, Small Nuclear
  • snRNP Core Proteins
  • DNA