Abstract
Folate monoglutamates and folate antagonists have an inhibitory action on the activity of 5,10-methylenetetrahydrofolate reductase in rat brain. The type of inhibition was studied for dihydrofolic acid using the Lineweaver--Burk transformation. Some of the monoamine alkaloids, the in vitro products of 5,10-methylenetetrahydrofolate reductase, have either a stimulatory or inhibitory effect on the enzyme activity.
MeSH terms
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Animals
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Biogenic Amines / pharmacology*
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Brain / enzymology*
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Folic Acid / analogs & derivatives*
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Folic Acid / pharmacology
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Folic Acid Antagonists / pharmacology*
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Kinetics
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Methylenetetrahydrofolate Dehydrogenase (NADP) / metabolism*
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Oxidoreductases / metabolism*
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Rats
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Rats, Inbred Strains
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Structure-Activity Relationship
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Substrate Specificity
Substances
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Biogenic Amines
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Folic Acid Antagonists
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Folic Acid
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Oxidoreductases
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Methylenetetrahydrofolate Dehydrogenase (NADP)