The Jo-1 antibody system in myositis: relationships to clinical features and HLA

J Rheumatol. Nov-Dec 1981;8(6):925-30.

Abstract

Antibodies to Jo-1, a saline extractable nuclear antigen, were found in 11/47 (23%) patients with myositis and in 0/35 controls with systemic lupus erythematosus or progressive systemic sclerosis (p less than or equal to 0.01). Within myositis subgroups, anti-Jo-1 occurred in 6/20 (30%) with polymyositis, 2/16 (13%) with dermatomyositis and 3/7 (43%) with overlap. There was an association between Jo-1 antibodies and HLA-DR3, irrespective of race or clinical subgroups (p less than or equal to 0.05). All anti-Jo-1 positive patients had either HLA-DR3, HLA-DRW6 or both (p less than or equal to 0.01). Thus, this antibody system might arise as a result of an aberrant immune response mediated at or near HLA-D in patients with myositis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Antinuclear / analysis*
  • Female
  • HLA Antigens / analysis
  • HLA Antigens / immunology*
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II
  • Humans
  • Myositis / immunology*
  • Myositis / physiopathology

Substances

  • Antibodies, Antinuclear
  • HLA Antigens
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II