Plasma concentrations in pyrimethamine and sulfadoxine and evaluation of pharmacokinetic data by computerized curve fitting

Bull World Health Organ. 1982;60(1):115-22.

Abstract

For the determination of the plasma concentration profiles of pyrimethamine and sulfadoxine after the administration of 1 tablet of Fansidar, highly specific analytical methods are needed as the pyrimethamine concentration is low (0.2 - 0.02 mg/litre) and the concentration ratio of the two components in the plasma is high (> 1: 500). The microbiological method described in this paper fulfils these requirements for high specificity and sensitivity (the sensitivity limit for sulfadoxine is 1 mg/litre and for pyrimethamine is 0.013 mg/litre).Pharmacokinetic data were evaluated for 14 volunteers after administration of 1 tablet of Fansidar, and a computer simulation of multiple dosing (1 tablet per week) was performed.

MeSH terms

  • Adult
  • Computers
  • Female
  • Humans
  • Kinetics
  • Male
  • Pyrimethamine / blood*
  • Sulfadoxine / blood*
  • Sulfanilamides / blood*

Substances

  • Sulfanilamides
  • Sulfadoxine
  • Pyrimethamine