Dose- and time-related effect of troleandomycin on methylprednisolone elimination

Clin Pharmacol Ther. 1982 Aug;32(2):166-71. doi: 10.1038/clpt.1982.143.


Effects of varying doses of troleandomycin (TAO) on methylprednisolone disposition were examined in five steroid-dependent asthmatic patients. The characteristic reduction in methylprednisolone elimination in the presence of TAO after a 40 mg IV methylprednisolone was also present after methylprednisolone doses as low as 4 mg. In patients receiving continuous TAO on an every-other-day basis, inhibition of methylprednisolone elimination was impaired to a greater extent on the "day on" TAO than on the "day off" TAO Methylprednisolone elimination on the day off TAO was still slower than that before TAO, however, TAO on a multiple-dose schedule resulted in greater reduction of methylprednisolone elimination than after a single TAO dose. These results suggest that TAO induces immediate and continued inhibition of methylprednisolone disposition.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Asthma / drug therapy*
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Drug Therapy, Combination
  • Humans
  • Kinetics
  • Methylprednisolone / metabolism*
  • Methylprednisolone / therapeutic use
  • Time Factors
  • Troleandomycin / administration & dosage*
  • Troleandomycin / therapeutic use


  • Troleandomycin
  • Methylprednisolone