High-altitude acclimatization and proteinuria in East Africa

Br J Dis Chest. 1978 Jul;72(3):196-8. doi: 10.1016/0007-0971(78)90041-4.


Seven climbers spent 6 weeks in the East African mountains, at heights of up to 5890 m. The mean protein urine concentration in morning specimens was over 100 mg/100 ml after climbs during the first 12 days but fell to 15 mg/100 ml during subsequent climbs. The highest concentrations (100-300 mg/100 ml) were in 5 climbers with peripheral oedema, 3 with obvious high-altitude illness. The findings implicate the kidney in high altitude acclimatization and illness.

MeSH terms

  • Acclimatization*
  • Africa, Eastern
  • Altitude*
  • Humans
  • Kidney / metabolism
  • Male
  • Proteinuria / metabolism*