Antibodies to adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: a nation-wide sero-epidemiologic study

Int J Cancer. 1982 Jun 15;29(6):631-5. doi: 10.1002/ijc.2910290606.


A nation-wide sero-epidemiologic survey of adult T-cell leukemia virus (ATLV), detected es anti-ATLA (ATLV-associated antigen), was made in Japan. Sera from adult donors in 15 different locations were screened for anti-ATLA. High incidences (6 to 37%) of antibody-positive donors were found in seven regions, one in northern Japan, and the others in southwestern regions. These areas are ATLV-endemic areas corresponding to ATL-endemic areas. Examination of sera from healthy donors aged 6 to 80 years in ATL-endemic areas showed an age-dependent increase of seropositive donors with a maximum of about 30% at 40 years of age. Anti-ATLA was found in all but two of 142 patients with ATL. Anti-ATLA-positive patients with ATL were mainly found in ATLV-endemic areas, and only a few in ATL-nonendemic areas. Six patients with cutaneous T-cell lymphoma in ATLV-nonendemic areas gave a negative reaction for anti-ATLA. The geometric mean titer of anti-ATLA of patients with ATL was higher than that of healthy donors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Antibodies, Neoplasm / analysis*
  • Antibodies, Viral / analysis*
  • Antigens, Neoplasm / immunology
  • Antigens, Viral / immunology*
  • Female
  • Humans
  • Japan
  • Leukemia / epidemiology
  • Leukemia / immunology*
  • Leukemia / microbiology
  • Lymphoma / immunology
  • Male
  • Middle Aged
  • Retroviridae / immunology*
  • Skin Neoplasms / immunology
  • T-Lymphocytes / immunology*


  • Antibodies, Neoplasm
  • Antibodies, Viral
  • Antigens, Neoplasm
  • Antigens, Viral