The effect of propranolol on portal hypertension in patients with cirrhosis: a hemodynamic study

Hepatology. Sep-Oct 1982;2(5):523-7. doi: 10.1002/hep.1840020502.

Abstract

The gradient between wedged and free hepatic venous pressures was measured in patients with alcoholic cirrhosis before and 1, 3, and 9 months after continuous oral administration of propranolol at doses reducing the heart rate by 25% or after administration of a placebo. The gradient between wedged and free hepatic venous pressures decreased throughout the duration of propranolol administration, and it did not significantly change in the patients receiving placebo. Since the gradient between wedged and free hepatic venous pressures closely reflects portal venous pressure in alcoholic cirrhosis, it is concluded that continuous oral administration of propranolol produced sustained reduction in portal venous pressure in these patients.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Cardiac Output / drug effects
  • Gastrointestinal Hemorrhage / prevention & control
  • Heart Rate / drug effects
  • Humans
  • Hypertension, Portal / complications
  • Hypertension, Portal / drug therapy*
  • Liver Circulation / drug effects
  • Liver Cirrhosis, Alcoholic / complications
  • Liver Cirrhosis, Alcoholic / drug therapy*
  • Propranolol / administration & dosage
  • Propranolol / therapeutic use*

Substances

  • Propranolol