Penetration of intravenously administered cefoxitin into the aqueous humor of inflamed human eyes

Am J Ophthalmol. 1982 Oct;94(4):516-8. doi: 10.1016/0002-9394(82)90246-x.


Intravenous injections of cefoxitin (2-g doses for adults and 40 mg/kg of body weight doses for children) were administered 90 minutes to two hours before surgery. All nine eyes had anterior segment inflammation. Samples of aqueous humor removed during surgery showed a mean cefoxitin concentration of 6.22 micrograms/ml, almost three times the concentration reported in uninflamed eyes. The greater penetration may have been the result of a breakdown in the blood-aqueous barrier. There were no complications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aqueous Humor / metabolism*
  • Cefoxitin / administration & dosage
  • Cefoxitin / metabolism*
  • Child
  • Endophthalmitis / metabolism*
  • Female
  • Humans
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Uveitis / metabolism*


  • Cefoxitin