Localisation of substance P immunoreactivity in amacrine cells of the retina

Nature. 1980 Jan 3;283(5742):87-8. doi: 10.1038/283087a0.


Since its actions on smooth muscle were first described by von Euler and Gaddum, substance P has been isolated and characterised as an undecapeptide. The distribution of substance P-like immunoreactivity in both the central and peripheral nervous systems and its reported excitatory action on neurones implicate substance P as a possible neurotransmitter and/or neuromodulator. Previous studies using bioassay and radioimmunoassay techniques have reported substance P in retinal extracts. Here we describe the specific immunohistochemical localisation of substance P-like immunoreactivity in a population of morphologically distinct amacrine cells of the pigeon retina. The localisation of substance P-like immunoreactivity and the recent localisation of enkephalin-like and somatostatin-like immunoreactivity in other types of amacrine cells suggest that the neuropeptides have a specific role in retinal function.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibody Specificity
  • Columbidae
  • Enkephalins / immunology
  • Enkephalins / metabolism
  • Immunologic Techniques
  • Retina / cytology
  • Retina / metabolism*
  • Substance P / immunology
  • Substance P / metabolism*


  • Enkephalins
  • Substance P