Clinical application of the HLA-B27 test in rheumatic diseases. A current perspective

Arch Intern Med. 1980 Feb;140(2):177-80.


Testing for the histocompatibility antigen HLA-B27 has been suggested as a valuable diagnostic aid in patients with ankylosing spondylitis and associated spondyloarthropathies, and B27 typing is becoming more readily available commercially at a number of clinical pathology laboratories. A current evaluation of B27 typing as a diagnostic test is presented, together with some guidelines for the clinical application of this test in the diagnosis of certain rheumatic diseases.

Publication types

  • Review

MeSH terms

  • Arthritis / diagnosis*
  • Arthritis, Juvenile / diagnosis
  • Arthritis, Reactive / diagnosis
  • Diagnosis, Differential
  • Female
  • HLA Antigens
  • Humans
  • Male
  • Prognosis
  • Spondylitis, Ankylosing / diagnosis


  • HLA Antigens