Family studies of ocular manifestations in arthritis

Can J Ophthalmol. 1978 Jul;13(3):144-51.


To determine the hereditary and clinical patterns, nine patients from three families with different systemic and ocular rheumatoid diseases were examined ophthalmologically and medically. Three types of HLA-B27 associated anterior uveitis were seen. While HLA-B27 linked genes predispose the carrier to acute anterior uveitis (AAU) frequently recurring or chronic anterior uveitis may develop if an immune-complex disease such as Rheumatoid arthritis coexists. Hereditary factors may dispose patients to rheumatoid episcleritis, scleritis and keratitis.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Arthritis, Rheumatoid / genetics*
  • Arthritis, Rheumatoid / immunology
  • Eye Diseases / genetics*
  • Eye Diseases / immunology
  • Eye Manifestations*
  • Female
  • HLA Antigens
  • Humans
  • Inflammation / genetics
  • Inflammation / immunology
  • Male
  • Middle Aged
  • Pedigree
  • Sacroiliac Joint
  • Sclera
  • Uveitis / genetics
  • Uveitis / immunology


  • HLA Antigens