Prevalence, pathogenesis, and functional significance of aldosterone deficiency in hyperkalemic patients with chronic renal insufficiency

Kidney Int. 1980 Jan;17(1):89-101. doi: 10.1038/ki.1980.11.

Abstract

Our findings indicate that hypoaldosteronism occurs commonly (23/31 patients) in hyperkalemic patients with chronic renal insufficiency and that the deficiency of aldosterone contributes to the pathogenesis of the hyperkalemia. In most patients (83%), hypoaldosteronism could be accounted for by deficient renal secretion of renin, but in some patients (17%) overt renin deficiency did not appear to be present, and therefore other (unidentified) causes of aldosterone deficiency must be invoked. The results also indicate that the urinary excretion rate of aldosterone secretion rate in this group of patients.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aldosterone / deficiency*
  • Aldosterone / metabolism
  • Chronic Disease
  • Diet, Sodium-Restricted
  • Female
  • Humans
  • Hyperkalemia / etiology
  • Hyperkalemia / metabolism*
  • Kidney Diseases / metabolism*
  • Male
  • Middle Aged
  • Nephritis, Interstitial / metabolism
  • Potassium / blood
  • Potassium / pharmacology
  • Renin / blood
  • Renin / metabolism
  • Renin / physiology
  • Sodium / blood

Substances

  • Aldosterone
  • Sodium
  • Renin
  • Potassium