Immunosuppressive therapy for external ocular inflammatory disease

Ophthalmology. 1980 Feb;87(2):140-50. doi: 10.1016/s0161-6420(80)35272-x.


Fourteen patients with progressive ocular inflammation and destructive lesions, unresponsive to conventional therapy, were treated with systemic immunosuppression. Ten patients had connective tissue/vasculitis diseases; two, cicatricial pemphigoid; and two, bilateral Mooren's corneal ulcers. Control of underlying systemic disease by immunosuppression resulted invariably in concomitant control of ocular inflammation and destruction. Encouraging results were obtained in the patients with cicatricial pemphigoid and those with bilateral Mooren's ulcers.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Connective Tissue Diseases / drug therapy*
  • Corneal Ulcer / drug therapy*
  • Eye Diseases / drug therapy*
  • Female
  • Granulomatosis with Polyangiitis / drug therapy
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Inflammation / drug therapy
  • Male
  • Middle Aged
  • Sclera / pathology
  • Sclera / transplantation
  • Skin Diseases, Vesiculobullous / drug therapy
  • Transplantation, Autologous


  • Immunosuppressive Agents