Mutagenicity of dichloroacetate, an ingredient of some formulations of pangamic acid (trade-named "vitamin B15")

Am J Clin Nutr. 1980 Jun;33(6):1179-82. doi: 10.1093/ajcn/33.6.1179.

Abstract

Dichloroacetate demonstrates low grade mutagenicity in the Ames Salmonella/mammaltan microsome mutagenicity test. This evidence of probable carcinogenicity must be considered in any proposed use of dichloroacetate or of preparations of pangamic acid (trade-named "vitamin B15") CONTAINING DICHLOROACETATE.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetates / pharmacology*
  • Animals
  • Aroclors / pharmacology
  • Calcium Gluconate
  • Carcinogens
  • Dichloroacetic Acid / pharmacology*
  • Microsomes, Liver
  • Mutagens*
  • N-substituted Glycines
  • Propylamines
  • Rats
  • Salmonella typhimurium / drug effects*
  • Salmonella typhimurium / genetics
  • Vitamin B Complex / adverse effects*

Substances

  • Acetates
  • Aroclors
  • Carcinogens
  • Mutagens
  • N-substituted Glycines
  • Propylamines
  • Vitamin B Complex
  • Dichloroacetic Acid
  • pangamic acid
  • Calcium Gluconate