Abstract
Dichloroacetate demonstrates low grade mutagenicity in the Ames Salmonella/mammaltan microsome mutagenicity test. This evidence of probable carcinogenicity must be considered in any proposed use of dichloroacetate or of preparations of pangamic acid (trade-named "vitamin B15") CONTAINING DICHLOROACETATE.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetates / pharmacology*
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Animals
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Aroclors / pharmacology
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Calcium Gluconate
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Carcinogens
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Dichloroacetic Acid / pharmacology*
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Microsomes, Liver
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Mutagens*
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N-substituted Glycines
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Propylamines
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Rats
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Salmonella typhimurium / drug effects*
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Salmonella typhimurium / genetics
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Vitamin B Complex / adverse effects*
Substances
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Acetates
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Aroclors
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Carcinogens
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Mutagens
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N-substituted Glycines
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Propylamines
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Vitamin B Complex
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Dichloroacetic Acid
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pangamic acid
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Calcium Gluconate