Plasma cholinesterase variants and the anaesthetist

Anaesthesia. 1980 Feb;35(2):174-97. doi: 10.1111/j.1365-2044.1980.tb03800.x.

Abstract

Biochemical properties of plasma cholinesterase of significance to the anaesthetist are reviewed. The role of the genetic variants of the enzyme in suxamethonium sensitivity and hyperthermia are discussed with emphasis on the pregnant patient. Altered gene frequencies of the enzyme variants in some mental disorders is commented upon.

Publication types

  • Review

MeSH terms

  • Adult
  • Anesthesia*
  • Apnea / drug therapy
  • Cholinesterases / blood
  • Cholinesterases / genetics*
  • Cholinesterases / therapeutic use
  • Female
  • Gene Frequency
  • Genes
  • Genetic Variation*
  • Genotype
  • Humans
  • Infant, Newborn
  • Male
  • Malignant Hyperthermia / enzymology
  • Malignant Hyperthermia / genetics
  • Pregnancy
  • Succinylcholine / adverse effects
  • Succinylcholine / metabolism

Substances

  • Cholinesterases
  • Succinylcholine