Inhibition of sterol biosynthesis in Candida albicans by imidazole-containing antifungals

J Gen Microbiol. 1980 Mar;117(1):253-5. doi: 10.1099/00221287-117-1-253.

Abstract

A simple procedure for studying sterol biosynthesis in cell-free homogenates of Candida albicans is described. The activities of some imidazole-containing antifungals (tioconazole, clotrimazole, econazole, ketoconazole and miconazole) as inhibitors of sterol C-14 demethylation have been determined using this technique.

Publication types

  • Comparative Study

MeSH terms

  • Antifungal Agents / pharmacology*
  • Candida albicans / drug effects
  • Candida albicans / metabolism*
  • Imidazoles / pharmacology*
  • Methods
  • Miconazole / pharmacology
  • Sterols / biosynthesis*

Substances

  • Antifungal Agents
  • Imidazoles
  • Sterols
  • Miconazole