Hemoglobin A Ic and diabetes mellitus

Annu Rev Med. 1980;31:29-34. doi: 10.1146/annurev.me.31.020180.000333.


Hemoglobin A Ic is produced when glucose reacts nonenzymatically with the NH2-termini of Hb A beta chains and then undergoes an Amadori rearrangement. The concentration of Hb A Ic measured at any given time reflects a patient's mean blood glucose level for the preceding weeks to months. Infrequent measurements of Hb A Ic can therefore be used to assess long-term carbohydrate control in outpatient diabetics. In addition, the synthesis of Hb A Ic may represent a model reaction to explain the pathogenesis of many of the sequelae of chronic diabetes. Nonenzymatic glycosylation reactions may also underlie some of the changes ascribed to normal aging.

Publication types

  • Review

MeSH terms

  • Blood Glucose / metabolism
  • Diabetes Complications
  • Diabetes Mellitus / blood*
  • Erythrocytes / metabolism
  • Female
  • Hemoglobin A / biosynthesis
  • Hemoglobin A / metabolism*
  • Humans
  • Male
  • Pregnancy


  • Blood Glucose
  • Hemoglobin A