A double-blind controlled clinical trial of carnidazole and tinidazole in the treatment of vaginal trichomoniasis

Eur J Obstet Gynecol Reprod Biol. 1980 Jun;10(5):325-8. doi: 10.1016/0028-2243(80)90080-5.


A double-blind controlled clinical trial of the new, not yet commercially available drug, carnidazole and tinidazole, was carried out in 77 women with a proven vaginal trichomoniasis. 39 patients and their sexual partners received a single dose of 2 g of carnidazole and the other 38 couples were treated in the same manner with tinidazole. The cure rate was 100% and 95% respectively. The side-effects were higher in the carnidazole group, although they were mild and well-tolerated by the patients and their partners. The history of the disease and its treatment are also briefly reviewed.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Nitroimidazoles / adverse effects
  • Nitroimidazoles / therapeutic use*
  • Tinidazole / adverse effects
  • Tinidazole / therapeutic use*
  • Trichomonas Vaginitis / drug therapy*


  • Nitroimidazoles
  • Tinidazole
  • carnidazole