Abstract
Reserpine (1 mg/kg) was administered to pregnant rats on days 12, 13 and 14 of gestation. Although adrenal tyrosine hydroxylase and dopamine beta-hydroxylase activities were normal in the offspring at 4 days of postnatal age, both were elevated by 17 days and the elevations persisted into adulthood. The changes may result from permanently increased sympatho-adrenal stimulation.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adrenal Glands / drug effects
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Adrenal Glands / enzymology*
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Animals
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Body Weight / drug effects
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Dopamine beta-Hydroxylase / metabolism*
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Female
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Pregnancy
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Reserpine / pharmacology*
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Stimulation, Chemical
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Tyrosine 3-Monooxygenase / metabolism*
Substances
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Reserpine
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Tyrosine 3-Monooxygenase
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Dopamine beta-Hydroxylase