Hypotensive effects of captopril administered centrally in intace conscious spontanously hypertensive rats and peripherally in anephric anaesthetized spontaneously hypertensive rats

Clin Exp Pharmacol Physiol. Sep-Oct 1980;7(5):555-8. doi: 10.1111/j.1440-1681.1980.tb00110.x.

Abstract

1. The hypotensive response to captopril in anaesthetized spontanously hypertensive rats (SHR) is not modified by bilateral nephrectomy performed 1 or 24 h previously. 2. Intracerebroventricular injection (i.c.v.) of captopril (2 mg kg-1) significantly lowered blood pressure of conscious SHR over a 7-h period of observation but there was no significant blood pressure response to i.c.v. vehicle, or to intravenous captopril (2 mg kg-1) in SHR. 3. There was no significant blood pressure response to captopril (2 mg kg-1) i.c.v. in the normotensive Wistar Kyoto controls (NT-WK). 4. These results indicate that captopril can lower the blood pressure of SHR by mechanisms independent of the kidneys or the circulating renin-angiotensin system. 5. The hypotensive effect of central captopril in SHR but not in the NT-WK suggests biochemical differences between the brains of the two rat strains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anesthesia
  • Animals
  • Blood Pressure / drug effects*
  • Captopril / administration & dosage*
  • Captopril / pharmacology
  • Captopril / therapeutic use
  • Consciousness
  • Hypertension / drug therapy*
  • Injections, Intravenous
  • Injections, Intraventricular
  • Male
  • Nephrectomy
  • Proline / analogs & derivatives*
  • Rats
  • Renin / physiology

Substances

  • Proline
  • Captopril
  • Renin