Multiple vascular malformation in the "blue rubber bleb naevus" syndrome: a case with aneurysm of vein of Galen and vascular lesions suggesting a link to the Weber-Osler-Rendu syndrome

Histopathology. 1978 Jul;2(4):301-11. doi: 10.1111/j.1365-2559.1978.tb01722.x.


A case of Bean's syndrome is reported in which a wide variety of vascular malformations are illustrated. Among these were multiple arterio-venous malformations including a so-called vein of Galen aneurysm. A comparison of this case with those in the literature suggests that the pathology in patients with Bean's syndrome may be more varied than heretofore recognized, and that an overlap between this syndrome and the Osler-Weber-Rendu syndrome may exist.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain / pathology
  • Esophagus / pathology
  • Gastrointestinal Neoplasms / pathology
  • Hemangioma, Cavernous / pathology*
  • Humans
  • Intracranial Aneurysm / pathology*
  • Male
  • Myocardium / pathology
  • Skin / pathology
  • Skin Neoplasms / pathology*
  • Syndrome
  • Telangiectasia, Hereditary Hemorrhagic / pathology