Sulfazecin and isosulfazecin, novel beta-lactam antibiotics of bacterial origin

Nature. 1981 Feb 12;289(5798):590-1. doi: 10.1038/289590a0.


In the long history of screening for antibiotics, fungi and actinomycetes have been the only producers of beta-lactam antibiotics although several phytopathogenic bacteria have been reported to produce toxins with a beta-lactam structure. We report here the first evidence that novel monocyclic beta-lactam antibiotics, sulfazecin and isosulfazecin, are produced by new species of Pseudomonas.

MeSH terms

  • Anti-Bacterial Agents / biosynthesis*
  • Dose-Response Relationship, Drug
  • Escherichia coli / drug effects
  • Monobactams*
  • Pseudomonas / metabolism*
  • beta-Lactams / pharmacology


  • Anti-Bacterial Agents
  • Monobactams
  • beta-Lactams
  • sulfazecin