Tolerance to the humoral and hemodynamic effects of caffeine in man

J Clin Invest. 1981 Apr;67(4):1111-7. doi: 10.1172/jci110124.


Acute caffeine in subjects who do not normally ingest methylxanthines leads to increases in blood pressure, heart rate, plasma epinephrine, plasma norepinephrine, plasma renin activity, and urinary catecholamines. Using a double-blind design, the effects of chronic caffeine administration on these same variables were assessed. Near complete tolerance, in terms of both humoral and hemodynamic variables, developed over the first 1-4 d of caffeine. No long-term effects of caffeine on blood pressure, heart rate, plasma renin activity, plasma catecholamines, or urinary catecholamines could be demonstrated. Discontinuation of caffeine ingestion after 7 d of administration did not result in a detectable withdrawal phenomenon relating to any of the variables assessed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Blood Pressure / drug effects
  • Caffeine / blood
  • Caffeine / pharmacology*
  • Catecholamines / blood*
  • Catecholamines / urine
  • Double-Blind Method
  • Drug Tolerance
  • Female
  • Hemodynamics / drug effects*
  • Humans
  • Male
  • Middle Aged
  • Renin / blood*


  • Catecholamines
  • Caffeine
  • Renin