Abstract
We have identified a new control or attenuator region in the chromosomal beta-lactamase operon of Escherichia coli. A single base alteration within its attenuator led to a loss in the cell's ability to coordinate its content of beta-lactamase with growth rate. We suggest a mechanism through which this mode of regulation operates.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Cloning, Molecular
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Escherichia coli / genetics*
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Escherichia coli / growth & development
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Gene Expression Regulation*
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Genes, Regulator*
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Models, Genetic
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Mutation
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Operon
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Plasmids
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Protein Biosynthesis
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Transcription, Genetic
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
Associated data
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GENBANK/J01583
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GENBANK/J01611