The E. coli beta-lactamase attenuator mediates growth rate-dependent regulation

Nature. 1981 Mar 19;290(5803):221-5. doi: 10.1038/290221a0.


We have identified a new control or attenuator region in the chromosomal beta-lactamase operon of Escherichia coli. A single base alteration within its attenuator led to a loss in the cell's ability to coordinate its content of beta-lactamase with growth rate. We suggest a mechanism through which this mode of regulation operates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Cloning, Molecular
  • Escherichia coli / genetics*
  • Escherichia coli / growth & development
  • Gene Expression Regulation*
  • Genes, Regulator*
  • Models, Genetic
  • Mutation
  • Operon
  • Plasmids
  • Protein Biosynthesis
  • Transcription, Genetic
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism


  • beta-Lactamases

Associated data

  • GENBANK/J01583
  • GENBANK/J01611