Regression on oxymetholone-induced hepatic tumors after bone marrow transplantation in aplastic anemia

Transplantation. 1980 Aug;30(2):90-6. doi: 10.1097/00007890-198008000-00002.

Abstract

Treatment of acquired aplastic anemia with androgens has been occasionally associated with the development of hepatic tumors. We have studied a 13-year-old boy with idiopathic aplastic anemia in whom oxymetholone treatment was associated with a partial hematological remission. Thirty-four months later, however, the patient developed multiple hepatic tumors. When oxymetholone therapy was discontinued, the aplastic anemia relapsed. He then underwent bone marrow transplantation from his HLA-A, B, and D-compatible sibling. This was followed by hematological and immunological reconstitution. The hepatic tumors underwent progressive regression after bone marrow transplantation. The patient is now 3 years post-bone marrow transplantation and is in complete remission of his aplastic anemia with no evidence of detectable liver tumors.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Anemia, Aplastic / complications*
  • Anemia, Aplastic / drug therapy
  • Bone Marrow Transplantation*
  • Humans
  • Liver Neoplasms / chemically induced
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / therapy*
  • Male
  • Oxymetholone / adverse effects*
  • Transplantation, Homologous
  • Ultrasonography

Substances

  • Oxymetholone