The ultrastructure of neurilemoma with emphasis on Antoni B tissue

Hum Pathol. 1981 Feb;12(2):145-60. doi: 10.1016/s0046-8177(81)80102-5.


Ten neurilemomas were studied by electron microscopy. Antoni A and B tissues were identified by light microscopy on semithin sections, and the corresponding areas on adjacent ultrathin sections were studied ultrastructurally. The Antoni B tissue definitely possessed features of degeneration in that the cells showed a detached basal lamina, a disrupted cell membrane, degenerated nuclei, and a significant accumulation of cytoplasmic granules and myelin figures. Added to these was intercellular edema with fibrin. The similarity of the granules in the cells of Antoni B tissue, cells of granular cell tumor, and Schwann cells in wallerian degeneration supports the conclusion that these three are related phenomena.

MeSH terms

  • Cytoplasmic Granules / ultrastructure
  • Granulosa Cell Tumor / ultrastructure
  • Histological Techniques
  • Humans
  • Microscopy
  • Microscopy, Electron
  • Neurilemmoma / ultrastructure*
  • Peripheral Nerves / ultrastructure
  • Schwann Cells / ultrastructure
  • Wallerian Degeneration