Radial glia of developing human fetal spinal cord: Golgi, immunohistochemical and electron microscopic study

Brain Res. 1981 Apr;227(2):249-67. doi: 10.1016/0165-3806(81)90112-7.


Radial glia of the developing spinal cord were examined by Golgi, electron microscopic and immunohistochemical methods in 40 human embryos and fetuses of ovulation age 6-20 weeks. As in developing cerebrum and cerebellum, gliogenesis in the spinal cord occurs much earlier than traditionally believed. The presence of transitional forms suggests that subependymal glia originate from detached radial glia that divide and differentiate in their new location. Well-differentiated astroglia evolve from radial glia as fetal age advances.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Astrocytes / cytology
  • Cell Differentiation
  • Female
  • Fluorescent Antibody Technique
  • Gestational Age
  • Glial Fibrillary Acidic Protein
  • Humans
  • Microscopy, Electron
  • Nerve Tissue Proteins / metabolism
  • Neuroglia / cytology*
  • Neurons / cytology
  • Pregnancy
  • Spinal Cord / embryology*


  • Glial Fibrillary Acidic Protein
  • Nerve Tissue Proteins