Effect of Positive-End-Expiratory-Pressure on Right Ventricular Output in Lambs With Hyaline Membrane Disease

Acta Paediatr Scand. 1980 Sep;69(5):603-6. doi: 10.1111/j.1651-2227.1980.tb07329.x.


Right and left ventricular outputs, pulmonary and systemic blood flows, and blood flows in both directions through the ductus arteriosus were measured before and during positive-end-expiratory-pressure in 5 premature lambs with induced hyaline membrane disease. During positive-end-expiratory-pressure, right ventricular output increased in all lambs without any significant change in left ventricular output or pulmonary vascular resistance. Left-to-right ductus flow decreased in lambs which initially had large left-to-right ductus shunts. significant right-to-left ductus flow did not occur before or during positive-end-expiratory-pressure.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cardiac Output*
  • Ductus Arteriosus / physiopathology
  • Hemodynamics
  • Humans
  • Hyaline Membrane Disease / physiopathology*
  • Hyaline Membrane Disease / therapy
  • Infant, Newborn
  • Intermittent Positive-Pressure Ventilation / methods*
  • Positive-Pressure Respiration / methods*
  • Sheep
  • Vascular Resistance