U-500 insulin in the treatment of antibody-mediated insulin resistance

Ann Intern Med. 1981 May;94(5):653-6. doi: 10.7326/0003-4819-94-5-653.


Three patients with antibody-mediated insulin resistance were treated with U-500 regular insulin subcutaneously. Insulin requirements decreased dramatically (55% to 75%) when therapy was changed from U-100 NPH pork to equivalent doses of U-500 regular pork insulin. There was no difference in antibody affinity for the insulin in these two preparations as shown by competition experiments. These observations demonstrate that U-500 insulin is a useful alternative in the treatment of antibody-mediated insulin resistance. The mechanism for this effect is yet to be determined.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Antibody Affinity
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / immunology
  • Female
  • Humans
  • Insulin / therapeutic use*
  • Insulin Antibodies / immunology*
  • Insulin Resistance*
  • Insulin, Isophane / therapeutic use
  • Insulin, Long-Acting / therapeutic use
  • Male
  • Middle Aged


  • Insulin
  • Insulin Antibodies
  • Insulin, Long-Acting
  • Insulin, Isophane